Open AccessBiogenesis, delivery, and function of extracellular RNA
Author(s) -
Patton James G.,
Franklin Jeffrey L.,
Weaver Alissa M.,
Vickers Kasey,
Zhang Bing,
Coffey Robert J.,
Mark Ansel K.,
Blelloch Robert,
Goga Andrei,
Huang Bo,
L'Etoille Noelle,
Raffai Robert L.,
Lai Charles P.,
Krichevsky Anna M.,
Mateescu Bogdan,
Greiner Vanille J.,
Hunter Craig,
Voinnet Olivier,
McManus Michael T.
Publication year - 2015
Publication title -
journal of extracellular vesicles
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.94
H-Index - 68
ISSN - 2001-3078
DOI - 10.3402/jev.v4.27494
Subject(s) - biogenesis , rna , function (biology) , extracellular , mechanism (biology) , microbiology and biotechnology , computational biology , biology , genetics , gene , philosophy , epistemology
The Extracellular RNA (exRNA) Communication Consortium was launched by the National Institutes of Health to focus on the extent to which RNA might function in a non‐cell‐autonomous manner. With the availability of increasingly sensitive tools, small amounts of RNA can be detected in serum, plasma, and other bodily fluids. The exact mechanism(s) by which RNA can be secreted from cells and the mechanisms for the delivery and uptake by recipient cells remain to be determined. This review will summarize current knowledge about the biogenesis and delivery of exRNA and outline projects seeking to understand the functional impact of exRNA.