Open AccessThe NIH Extracellular RNA Communication Consortium
Author(s) -
Ainsztein Alexandra M.,
Brooks Philip J.,
Dugan Vivien G.,
Ganguly Aniruddha,
Guo Max,
Howcroft T. Kevin,
Kelley Christine A.,
Kuo Lillian S.,
Labosky Patricia A.,
Lenzi Rebecca,
McKie George A.,
Mohla Suresh,
Procaccini Dena,
Reilly Matthew,
Satterlee John S.,
Srinivas Pothur R.,
Stansell Church Elizabeth,
Sutherland Margaret,
Tagle Danilo A.,
Tucker Jessica M.,
Venkatachalam Sundar
Publication year - 2015
Publication title -
journal of extracellular vesicles
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.94
H-Index - 68
ISSN - 2001-3078
DOI - 10.3402/jev.v4.27493
Subject(s) - resource (disambiguation) , computational biology , computer science , medicine , biology , computer network
The Extracellular RNA (exRNA) Communication Consortium, funded as an initiative of the NIH Common Fund, represents a consortium of investigators assembled to address the critical issues in the exRNA research arena. The overarching goal is to generate a multi‐component community resource for sharing fundamental scientific discoveries, protocols, and innovative tools and technologies. The key initiatives include (a) generating a reference catalogue of exRNAs present in body fluids of normal healthy individuals that would facilitate disease diagnosis and therapies, (b) defining the fundamental principles of exRNA biogenesis, distribution, uptake, and function, as well as development of molecular tools, technologies, and imaging modalities to enable these studies, (c) identifying exRNA biomarkers of disease, (d) demonstrating clinical utility of exRNAs as therapeutic agents and developing scalable technologies required for these studies, and (e) developing a community resource, the exRNA Atlas, to provide the scientific community access to exRNA data, standardized exRNA protocols, and other useful tools and technologies generated by funded investigators.