Open AccessNutmeg oil alleviates chronic inflammatory pain through inhibition of COX-2 expression and substance P release in vivo
Author(s) -
Wei Kevin Zhang,
Shan-Shan Tao,
Tingting Li,
Yu-Sang Li,
Xiaojun Li,
He-Bin Tang,
Rongjuan Cong,
Fangli Ma,
Wan Chu-Jun
Publication year - 2016
Publication title -
food and nutrition research/food and nutrition research. supplement
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.041
H-Index - 37
eISSN - 1654-6628
pISSN - 1654-661X
DOI - 10.3402/fnr.v60.30849
Subject(s) - nutmeg , medicine , chronic pain , analgesic , in vivo , pharmacology , hyperalgesia , diabetes mellitus , traditional medicine , microbiology and biotechnology , physical therapy , biology , receptor , nociception , endocrinology
Background Chronic pain, or sometimes referred to as persistent pain, reduces the life quality of patients who are suffering from chronic diseases such as inflammatory diseases, cancer and diabetes. Hence, herbal medicines draw many attentions and have been shown effective in the treatment or relief of pain. Methods and Results Here in this study, we used the CFA-injected rats as a sustainable pain model to test the anti-inflammatory and analgesic effect of nutmeg oil, a spice flavor additive to beverages and baked goods produced from the seed of Myristica fragrans tree. Conclusions We have demonstrated that nutmeg oil could potentially alleviate the CFA-injection induced joint swelling, mechanical allodynia and heat hyperanalgesia of rats through inhibition of COX-2 expression and blood substance P level, which made it possible for nutmeg oil to be a potential chronic pain reliever.