Open AccessThe differential effects of green tea on dose-dependent doxorubicin toxicity
Author(s) -
Sławomir Mańdziuk,
Renata Gieroba,
Agnieszka Korga,
W Matysiak,
Barbara JodłowskaJędrych,
Franciszek Burdan,
Ewa Poleszak,
Michał Kowalczyk,
Luiza Grzycka-Kowalczyk,
E Korobowicz,
Aleksandra Józefczyk,
Jarosław Dudka
Publication year - 2015
Publication title -
food and nutrition research/food and nutrition research. supplement
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.041
H-Index - 37
eISSN - 1654-6628
pISSN - 1654-661X
DOI - 10.3402/fnr.v59.29754
Subject(s) - oxidative stress , cardiotoxicity , doxorubicin , pharmacology , toxicity , medicine , superoxide dismutase , drug , endocrinology , chemotherapy
Background Doxorubicin (DOX) is an anticancer drug displaying cardiac and hepatic adverse effects mostly dependent on oxidative stress. Green tea (GT) has been reported to play a protective role in diseases resulting from oxidative stress. Objective The objective of this study was to evaluate if GT protects against DOX-induced oxidative stress, heart and liver morphological changes, and metabolic disorders. Methods Male Wistar rats received intraperitoneal injection of DOX (1.0 or 2.0 mg/kg b.w.) for 7 weeks or concomitantly GT extract soluble in drinking water. Results There were multidirectional effects of GT on blood metabolic parameters changed by DOX. Among all tested biochemical parameters, statistically significant protection of GT against DOX-induced changes was revealed in case of blood fatty acid–binding protein, brain natriuretic peptide, and superoxide dismutase. Conclusion DOX caused oxidative stress in both organs. It was inhibited by GT in the heart but remained unchanged in the liver. DOX-induced general toxicity and histopathological changes in the heart and in the liver were mitigated by GT at a higher dose of DOX and augmented in rats treated with a lower dose of the drug.