Open AccessPomegranate(Punicagranatum)juice decreases lipid peroxidation, but has no effect on plasma advanced glycated end-products in adults with type 2 diabetes: a randomized double-blind clinical trial
Author(s) -
Golbon Sohrab,
Pooneh Angoorani,
Maryam Tohidi,
Hadi Tabibi,
Masoud Kimiagar,
Javad Nasrollahzadeh
Publication year - 2015
Publication title -
food and nutrition research/food and nutrition research. supplement
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.041
H-Index - 37
eISSN - 1654-6628
pISSN - 1654-661X
DOI - 10.3402/fnr.v59.28551
Subject(s) - pentosidine , lipid peroxidation , malondialdehyde , oxidative stress , medicine , type 2 diabetes , placebo , endocrinology , diabetes mellitus , randomized controlled trial , type 2 diabetes mellitus , glycation , pathology , alternative medicine
Diabetes mellitus characterized by hyperglycemia could increase oxidative stress and formation of advanced glycated end-products (AGEs), which contribute to diabetic complications. The purpose of this study was to assess the effect of pomegranate juice (PJ) containing natural antioxidant on lipid peroxidation and plasma AGEs in patients with type 2 diabetes (T2D). Materials and methods In a randomized, double-blind, placebo-controlled trial, 44 patients (age range 56±6.8 years), T2D were randomly assigned to one of two groups: group A (PJ, n =22) and group B (Placebo, n =22). At the baseline and the end of 12-week intervention, biochemical markers including fasting plasma glucose, insulin, oxidative stress, and AGE markers including carboxy methyl lysine (CML) and pentosidine were assayed. Results At baseline, there were no significant differences in plasma total antioxidant capacity (TAC) levels between the two groups, but malondialdehyde (MDA) decreased levels were significantly different ( P <0.001). After 12 weeks of intervention, TAC increased ( P <0.05) and MDA decreased ( P <0.01) in the PJ group when compared with the placebo group. However, no significant differences were observed in plasma concentration of CML and pentosidine between the two groups. Conclusions The study showed that PJ decreases lipid peroxidation. Therefore, PJ consumption may delay onset of T2D complications related to oxidative stress.