Open AccessNovel Approaches to Enhance Oral Bioavailability of Poorly Soluble Drugs
Author(s) -
Buduru Gowthami,
S. Krishna,
D. Subba Rao
Publication year - 2020
Publication title -
international journal of research in pharmaceutical sciences and technology
Language(s) - English
Resource type - Journals
ISSN - 2581-9143
DOI - 10.33974/ijrpst.v2i1.231
Subject(s) - nanocarriers , bioavailability , oral route , drug , solubility , pharmacology , drug delivery , chemistry , nanotechnology , biochemical engineering , medicine , materials science , engineering , organic chemistry
Oral administration is considered as major, convenient route among all other routes of delivery, owing to several benefits. But, the poor solubility or enzymatic/metabolic activity are the major concerns in developing a successful formulation. About 40% of approved drugs which are in the current market and 90% of new drug molecules in the developmental pipeline are hydrophobic in nature. The challenge to formulate insoluble drugs has met with various approaches to overcome the problems related to solubility, application of nanotechnology is one amongst them. The present review deals with various nanocarriers and technologies that are proven to be effective in enhancing the bioavilability of poorly soluble drugs.