Open AccessThe evolution of eloquent located low-grade gliomas surgical approaches, their natural history and molecular classification
Author(s) -
Mihaela Coșman,
Andrei Ionuţ Cucu,
Alin Constantin Iordache,
B. Iliescu,
Gabriela Florența Dumitrecu,
Dana Mihaela Turliuc
Publication year - 2021
Publication title -
romanian neurosurgery
Language(s) - English
Resource type - Journals
eISSN - 2344-4959
pISSN - 1220-8841
DOI - 10.33962/roneuro-2021-007
Subject(s) - medicine , natural history , glioma , white matter , neurosurgery , risk stratification , surgical resection , radiology , magnetic resonance imaging , cancer research
Low-grade glioma is characterized by slow growth, infiltrative pattern through white matter tracts and progression to a malignant tumour type. The traditional classification is newly replaced by molecular stratification. This reorganisation gathers glioma with similar prognosis and treatment protocols. The preferential location of that tumour in eloquent areas constituted, over time, a real challenge regarding the best surgical approach. Because of the high risk of postoperative neurological deficits initially a more conservative management was adopted. Once with the development of preoperative and intraoperative functional assessment techniques, a higher degree of resection was possible in the limits of cortico-subcortical eloquence, being well known that this is a statistically significant factor for survival. We present in this paper the natural evolution of low-grade glioma, their new molecular classification, prognostic factors and the various approach proposed for eloquent ones.