Open AccessRelationship Between Oxidative Stress Parameters and Cystatin C Levels in Patients With Severe Preeclampsia
Author(s) -
Şaban Yalçın,
Turgay Ulaş,
Mehmet Ali Eren,
Harun Aydoğan,
Aysun Camuzcuoğlu,
Ahmet Küçük,
Hasan Hüsnü Yüce,
Mehmet Emin Demir,
Mehmet Vural,
Nurten Aksoy
Publication year - 2013
Publication title -
medicina
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.53
H-Index - 36
eISSN - 1648-9144
pISSN - 1010-660X
DOI - 10.3390/medicina49030019
Subject(s) - oxidative stress , cystatin c , medicine , preeclampsia , antioxidant capacity , antioxidant , endocrinology , creatinine , pregnancy , chemistry , biology , biochemistry , genetics
Background and Objective. Oxidative stress is believed to play a role in the development of preeclampsia (PE). It is known that an increased cystatin C level is also associated with PE. The aim of this study was to investigate the relationship between oxidative stress parameters and cystatin C levels in patients with severe PE. Material and Methods. Forty-four patients with severe PE and 40 healthy pregnant women were recruited for the study. All study subjects were divided into 2 groups: group 1 (n=44) consisted of patients with severe PE, and group 2 (n=40) included healthy pregnant subjects. Blood samples were obtained from all subjects in order to measure the cystatin C level, total antioxidant status, and total oxidant status. The oxidative stress index was calculated. Results. The group 1 had significantly higher cystatin C, total oxidant status, oxidative stress index levels and lower total antioxidant status level as compared with the group 2 (P=0.001, P<0.001, P<0.001, P=0.036, respectively). The serum cystatin C level was significantly correlated with the oxidative stress index (r=0.609, P<0.001). Conclusions. The present study demonstrated that both oxidative stress and cystatin C levels were increased in patients with PE, and the increased cystatin C levels seem to be a consequence of oxidative stress. Correspondence to