Open AccessFlavones: Six Selected Flavones and Their Related Signaling Pathways That Induce Apoptosis in Cancer
Author(s) -
Se Hyo Jeong,
Hun Hwan Kim,
Sang Eun Ha,
Min Young Park,
Pritam Bhagwan Bhosale,
Abuyaseer Abusaliya,
Kwang Il Park,
Jeong Doo Heo,
HyunWook Kim,
Gon Sup Kim
Publication year - 2022
Publication title -
international journal of molecular sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.455
H-Index - 162
eISSN - 1661-6596
pISSN - 1422-0067
DOI - 10.3390/ijms231810965
Subject(s) - flavones , wogonin , baicalein , apigenin , apoptosis , luteolin , cancer , cancer cell , programmed cell death , signal transduction , acacetin , nobiletin , chemistry , biology , cancer research , scutellaria baicalensis , pharmacology , biochemistry , medicine , flavonoid , botany , traditional chinese medicine , genetics , pathology , alternative medicine , antioxidant
Cancer is a horrific disease that, to date, has no cure. It is caused by various factors and takes many lives. Apoptosis is a programmed cell death mechanism and if it does not function correctly in cancer cells, it can lead to severe disease. There are various signaling pathways for regulating apoptosis in cancer cells. Flavonoids are non-artificial natural bioactive compounds that are gaining attention as being capable of for inducing apoptosis in cancer cells. Among these, in this study, we focus on flavones. Flavones are a subclass of the numerous available flavonoids and possess several bioactive functions. Some of the most reported and well-known critical flavones, namely apigenin, acacetin, baicalein, luteolin, tangeretin, and wogonin, are discussed in depth in this review. Our main aim is to investigate the effects of the selected flavones on apoptosis and cell signaling pathways that contribute to death due to various types of cancers.