Open AccessStudy of a Series of 8-Substitued 7-hydroxy-4-methylcoumarins as AChE and BuChE Inhibitors
Author(s) -
María João Matos,
Fernanda Borges,
Lourdes Santana,
Eugenio Uriarte,
Rosaria Medda,
Adriana Murgia,
Amalia Di Petrillo,
Benedetta Era,
Antonella Fais,
Francesca Pintus
Publication year - 2015
Language(s) - English
Resource type - Conference proceedings
DOI - 10.3390/ecmc-1-a027
Subject(s) - butyrylcholinesterase , acetylcholinesterase , aché , series (stratigraphy) , enzyme , cholinesterase , chemistry , biochemistry , combinatorial chemistry , pharmacology , biology , paleontology
In the current work we studied the interest of a series of 8-substitued 7-hydroxy-4-methylcoumarins as acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE) inhibitors. For the best compounds of the series, the IC50 value was determined. This work was based on previous results and is a preliminary screening for further design and synthesis of new derivatives as potential compounds that can modulate enzymatic systems involved in the neurodegenerative diseases