Study of a Series of 8-Substitued 7-hydroxy-4-methylcoumarins as AChE and BuChE Inhibitors | Zendy

María João Matos | Zendy; Fernanda Borges | Zendy; Lourdes Santana | Zendy; Eugenio Uriarte | Zendy; Rosaria Medda | Zendy; Adriana Murgia | Zendy; Amalia Di Petrillo | Zendy; Benedetta Era | Zendy; Antonella Fais | Zendy; Francesca Pintus | Zendy

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Study of a Series of 8-Substitued 7-hydroxy-4-methylcoumarins as AChE and BuChE Inhibitors

Author(s) -

María João Matos,

Fernanda Borges,

Lourdes Santana,

Eugenio Uriarte,

Rosaria Medda,

Adriana Murgia,

Amalia Di Petrillo,

Benedetta Era,

Antonella Fais,

Francesca Pintus

Publication year - 2015

Language(s) - English

Resource type - Conference proceedings

DOI - 10.3390/ecmc-1-a027

Subject(s) - butyrylcholinesterase , acetylcholinesterase , aché , series (stratigraphy) , enzyme , chemistry , combinatorial chemistry , biochemistry , stereochemistry , biology , paleontology

In the current work we studied the interest of a series of 8-substitued 7-hydroxy-4-methylcoumarins as acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE) inhibitors. For the best compounds of the series, the IC50 value was determined. This work was based on previous results and is a preliminary screening for further design and synthesis of new derivatives as potential compounds that can modulate enzymatic systems involved in the neurodegenerative diseases

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