Association Between 12 Polymorphisms of VEGF/Hypoxia/Angiogenesis Pathway Genes and Risk of Urogenital Carcinomas: A Meta-Analysis Based on Case-Control Studies | Zendy

Jinbo Chen | Zendy; Meng Zhang | Zendy; Yu Cui | Zendy; Peihua Liu | Zendy; Weiqi Yan | Zendy; Chao Li | Zendy; Cheng Xu | Zendy; Wenbiao Ren | Zendy; Qiaqia Li | Zendy; Longfei Liu | Zendy; Minfeng Chen | Zendy; Hequn Chen | Zendy; Xiongbing Zu | Zendy

Open Access

Association Between 12 Polymorphisms of VEGF/Hypoxia/Angiogenesis Pathway Genes and Risk of Urogenital Carcinomas: A Meta-Analysis Based on Case-Control Studies

Author(s) -

Jinbo Chen,

Meng Zhang,

Yu Cui,

Peihua Liu,

Weiqi Yan,

Chao Li,

Cheng Xu,

Wenbiao Ren,

Qiaqia Li,

Longfei Liu,

Minfeng Chen,

Hequn Chen,

Xiongbing Zu

Publication year - 2018

Publication title -

frontiers in physiology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.32

H-Index - 102

ISSN - 1664-042X

DOI - 10.3389/fphys.2018.00715

Subject(s) - oncology , odds ratio , angiogenesis , enos , meta analysis , genitourinary system , medicine , single nucleotide polymorphism , biology , vascular endothelial growth factor , case control study , allele , cancer research , genotype , bioinformatics , genetics , gene , vegf receptors , nitric oxide , nitric oxide synthase

Objective: Previous studies indicated potential associations between polymorphisms in genes of VEGF/hypoxia/angiogenesis pathway and risk of urogenital carcinomas However, the results were controversial and inconclusive. Here, we conducted an in-depth meta-analysis to investigate the precise associations between polymorphisms in VEGF/hypoxia/angiogenesis related genes and risk of urogenital carcinomas. Methods: We searched PubMed, Web of Science, EMBASE, and Cochrane Library to identify all eligible publications. Pooled odds ratios (ORs) corresponding with the 95% confidence intervals (CIs) were calculated to evaluate their associations. Subgroup analysis was conducted to further ascertain such relationship and investigate sources of heterogeneity. Results: In the end, a total of 96 case-control studies fulfilled the inclusion criteria were enrolled for 12 polymorphisms in 4 VEGF/hypoxia/angiogenesis related genes. The pooled results showed eNOS-rs2070744 polymorphism conferred a significantly increased overall risk of urogenital carcinomas in allele, homozygote, and recessive models, respectively. In addition, eNOS-Intron 4a/b VNTR polymorphism was identified related to an increased risk of urogenital carcinomas in recessive model. And VEGF-rs699947 polymorphism was also identified an increased risk of renal cell carcinoma (RCC) in allelic, heterozygote, dominant, homozygote, and recessive models. Conclusion: To conclude, eNOS-rs2070744 and eNOS-Intron 4a/b VNTR polymorphisms are risk factors for urogenital carcinomas. VEGF-rs699947 polymorphism was also identified as an increased risk factor for renal carcinoma.

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