Long Non-coding Wilms Tumor 1 Antisense RNA in the Development and Progression of Malignant Tumors | Zendy

Ye Zhang | Zendy; Linjun Fan | Zendy; Yi Zhang | Zendy; Jun Jiang | Zendy; Xiaowei Qi | Zendy

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Long Non-coding Wilms Tumor 1 Antisense RNA in the Development and Progression of Malignant Tumors

Author(s) -

Ye Zhang,

Linjun Fan,

Yi Zhang,

Jun Jiang,

Xiaowei Qi

Publication year - 2020

Publication title -

frontiers in oncology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.834

H-Index - 83

ISSN - 2234-943X

DOI - 10.3389/fonc.2020.00035

Subject(s) - wilms' tumor , cancer research , tumor progression , long non coding rna , cancer , antisense rna , colorectal cancer , rna , medicine , biology , gene , genetics

A growing number of studies have shown that long non-coding RNAs (lncRNAs) play an important role in tumor development and progression and are key molecules affecting tumor progression. The lncRNA Wilms tumor 1 antisense RNA (WT1-AS) is specifically expressed in various malignant tumors. In particular, WT1-AS expression is upregulated in colon cancer and breast cancer but is significantly downregulated in cervical cancer, liver cancer, and kidney cancer. The level of WT1-AS expression is closely related to the size, stage, and patient survival rate of these cancers. In this article, we review the modes of action, expression, function, and mechanisms of WT1-AS in different tumors to provide new targets for tumor diagnosis and treatment.

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