Open AccessPA28α/β Promote Breast Cancer Cell Invasion and Metastasis via Down-Regulation of CDK15
Author(s) -
Shengnan Li,
Xiaoqin Dai,
Kunxiang Gong,
Kai Song,
Fang Tai,
Jian Shi
Publication year - 2019
Publication title -
frontiers in oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.834
H-Index - 83
ISSN - 2234-943X
DOI - 10.3389/fonc.2019.01283
Subject(s) - cancer research , metastasis , gene knockdown , gene silencing , breast cancer , cell migration , metastatic breast cancer , cancer , biology , cell , medicine , cell culture , biochemistry , genetics , gene
PA28α/β activated immunoproteasome frequently participates in MHC class I antigen processing, however, whether it is involved in breast tumor progression remains largely unclear. Here, our evidences show that PA28α/β proteins are responsible for breast cancer cell migration, invasion, and metastasis. Knockdown of immunoproteasome core subunit β5i also robustly suppresses the tumor cell migration and invasion. Interestingly, silencing of PA28α/β and β5i up-regulates the protein expression of cyclin-dependent kinase 15 (CDK15). Our data further indicate that the loss of CDK15 is important for breast tumor cell invasion and metastasis. Taken together, this study implicates that targeting of PA28α/β represents a potential way for treatment of metastatic breast cancer.