Editing the Central Nervous System Through CRISPR/Cas9 Systems | Zendy

Agustín Cota-Coronado | Zendy; Néstor Fabián Díaz-Martínez | Zendy; Eduardo PadillaCamberos | Zendy; Emmanuel Diaz | Zendy

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Editing the Central Nervous System Through CRISPR/Cas9 Systems

Author(s) -

Agustín Cota-Coronado,

Néstor Fabián Díaz-Martínez,

Eduardo PadillaCamberos,

Emmanuel Diaz

Publication year - 2019

Publication title -

frontiers in molecular neuroscience

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.989

H-Index - 63

ISSN - 1662-5099

DOI - 10.3389/fnmol.2019.00110

Subject(s) - crispr , genome editing , neurodegeneration , neuroscience , cas9 , disease , genetic enhancement , central nervous system , parkinson's disease , translational research , medicine , biology , computer science , gene , pathology , genetics

The translational gap to treatments based on gene therapy has been reduced in recent years because of improvements in gene editing tools, such as the CRISPR/Cas9 system and its variations. This has allowed the development of more precise therapies for neurodegenerative diseases, where access is privileged. As a result, engineering of complexes that can access the central nervous system (CNS) with the least potential inconvenience is fundamental. In this review article, we describe current alternatives to generate systems based on CRISPR/Cas9 that can cross the blood–brain barrier (BBB) and may be used further clinically to improve treatment for neurodegeneration in Parkinson’s and Alzheimer’s disease (AD).

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