Open AccessAlteration in Functional Magnetic Resonance Imaging Signal Complexity Across Multiple Time Scales in Patients With Migraine Without Aura
Author(s) -
Xiao Wang,
Yutong Zhang,
Wenchuan Qi,
Tao Xu,
Ziwen Wang,
Huaqiang Liao,
Yanan Wang,
Jie Liu,
Yang Yu,
Zhenxi He,
Shan Gao,
Dehua Li,
Guilin Zhang,
Ling Zhao
Publication year - 2022
Publication title -
frontiers in neuroscience
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.499
H-Index - 102
eISSN - 1662-4548
pISSN - 1662-453X
DOI - 10.3389/fnins.2022.825172
Subject(s) - aura , postcentral gyrus , functional magnetic resonance imaging , migraine , default mode network , migraine with aura , neuroscience , psychology , brain activity and meditation , audiology , medicine , electroencephalography
Background Migraine is a primary neurological disorder associated with complex brain activity. Recently, mounting evidence has suggested that migraine is underpinned by aberrant dynamic brain activity characterized by linear and non-linear changes across a variety of time scales. However, the abnormal dynamic brain activity at different time scales is still unknown in patients with migraine without aura (MWoA). This study aimed to assess the altered patterns of brain activity dynamics over different time scales and the potential pathophysiological mechanisms of alterations in patients with MWoA. Methods Multiscale entropy in 50 patients and 20 healthy controls (HCs) was calculated to investigate the patterns and altered brain complexity (BC) across five different time scales. Spearman rank correlation analysis between BC in regions showing significant intergroup differences and clinical scores (i.e., frequency of migraine attacks, duration, headache impact test) was conducted in patients with MWoA. Results The spatial distribution of BC varied across different time scales. At time scale1, BC was higher in the posterior default mode network (DMN) across participants. Compared with HCs, patients with MWoA had higher BC in the DMN and sensorimotor network. At time scale2, BC was mainly higher in the anterior DMN across participants. Patients with MWoA had higher BC in the sensorimotor network. At time scale3, BC was mainly higher in the frontoparietal network across participants. Patients with MWoA had increased BC in the parietal gyrus. At time scale4, BC is mainly higher in the sensorimotor network. Patients with MWoA had higher BC in the postcentral gyrus. At time scale5, BC was mainly higher in the DMN. Patients with MWoA had lower BC in the posterior DMN. In particular, BC values in the precuneus and paracentral lobule significantly correlated with clinical symptoms. Conclusion Migraine is associated with alterations in dynamic brain activity in the sensorimotor network and DMN over multiple time scales. Time-varying BC within these regions could be linked to instability in pain transmission and modulation. Our findings provide new evidence for the hypothesis of abnormal dynamic brain activity in migraine.