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Two metal oxide (i.e., Al 2 O 3  and TiO 2 ) nanoparticles and ajoene, a garlic-derived organosulfur compound, were identified to be effective antimicrobials against  Campylobacter jejuni , a leading cause of human gastrointestinal diseases worldwide. A significant synergistic antimicrobial effect was observed using ajoene and Al 2 O 3 /TiO 2  nanoparticles in a combined manner to cause at least 8 log 10  CFU/mL reduction of  C. jejuni  cells. Whole transcriptome sequencing (RNA-seq) and confocal micro-Raman spectroscopic analyses revealed the antimicrobial mechanism and identified the roles of ajoene and metal oxide nanoparticles in the synergistic treatment. Ajoene and metal oxide nanoparticles mediated a two-phase antimicrobial mechanism. Ajoene served as the inducing factor at the first phase that caused injury of cell membranes and increased the susceptibility of  C. jejuni  to stress. Metal oxide nanoparticles served as the active factor at the second phase that targeted sensitive cells and physically disrupted cell structure. This synergistic antimicrobial treatment demonstrates a potential to reduce the prevalence of  C. jejuni  and other pathogens on food contact surfaces and in the food chain.

Whole Transcriptome Sequencing Analysis of the Synergistic Antimicrobial Effect of Metal Oxide Nanoparticles and Ajoene on Campylobacter jejuni