Open AccessPerihematomal Edema After Intracerebral Hemorrhage: An Update on Pathogenesis, Risk Factors, and Therapeutic Advances
Author(s) -
Yi-Hao Chen,
Shengpan Chen,
Jinyuan Chang,
Junji Wei,
Ming Feng,
Renzhi Wang
Publication year - 2021
Publication title -
frontiers in immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.646
H-Index - 124
ISSN - 1664-3224
DOI - 10.3389/fimmu.2021.740632
Subject(s) - medicine , intracerebral hemorrhage , hematoma , mechanism (biology) , intensive care medicine , edema , pathogenesis , brain edema , therapeutic effect , stroke (engine) , therapeutic approach , bioinformatics , surgery , subarachnoid hemorrhage , disease , mechanical engineering , philosophy , epistemology , engineering , biology
Intracerebral hemorrhage (ICH) has one of the worst prognoses among patients with stroke. Surgical measures have been adopted to relieve the mass effect of the hematoma, and developing targeted therapy against secondary brain injury (SBI) after ICH is equally essential. Numerous preclinical and clinical studies have demonstrated that perihematomal edema (PHE) is a quantifiable marker of SBI after ICH and is associated with a poor prognosis. Thus, PHE has been considered a promising therapeutic target for ICH. However, the findings derived from existing studies on PHE are disparate and unclear. Therefore, it is necessary to classify, compare, and summarize the existing studies on PHE. In this review, we describe the growth characteristics and relevant underlying mechanism of PHE, analyze the contributions of different risk factors to PHE, present the potential impact of PHE on patient outcomes, and discuss the currently available therapeutic strategies.