Insights Into the Role of Endoplasmic Reticulum Stress in Infectious Diseases | Zendy

Jiae Choi | Zendy; ChangHwa Song | Zendy

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Insights Into the Role of Endoplasmic Reticulum Stress in Infectious Diseases

Author(s) -

Jiae Choi,

ChangHwa Song

Publication year - 2020

Publication title -

frontiers in immunology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.646

H-Index - 124

ISSN - 1664-3224

DOI - 10.3389/fimmu.2019.03147

Subject(s) - unfolded protein response , endoplasmic reticulum , innate immune system , microbiology and biotechnology , protein folding , signal transduction , immune system , pathogenesis , biology , immunology

The endoplasmic reticulum (ER) is the major organelle in the cell for protein folding and plays an important role in cellular functions. The unfolded protein response (UPR) is activated in response to misfolded or unfolded protein accumulation in the ER. However, the UPR successfully alleviates the ER stress. If UPR fails to restore ER homeostasis, apoptosis is induced. ER stress plays an important role in innate immune signaling in response to microorganisms. Dysregulation of UPR signaling contributes to the pathogenesis of a variety of infectious diseases. In this review, we summarize the contribution of ER stress to the innate immune response to invading microorganisms and its role in the pathogenesis of infectious diseases.

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