TGF-β-Induced Endothelial to Mesenchymal Transition in Disease and Tissue Engineering | Zendy

Jin Ma | Zendy; Gonzalo SánchezDuffhues | Zendy; MarieJosé Goumans | Zendy; Peter ten Dijke | Zendy

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TGF-β-Induced Endothelial to Mesenchymal Transition in Disease and Tissue Engineering

Author(s) -

Jin Ma,

Gonzalo SánchezDuffhues,

MarieJosé Goumans,

Peter ten Dijke

Publication year - 2020

Publication title -

frontiers in cell and developmental biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.452

H-Index - 53

ISSN - 2296-634X

DOI - 10.3389/fcell.2020.00260

Subject(s) - mesenchymal stem cell , transforming growth factor , fibrosis , epithelial–mesenchymal transition , embryonic stem cell , cancer research , transforming growth factor beta , microbiology and biotechnology , signal transduction , tissue engineering , cancer , immunology , biology , medicine , pathology , metastasis , genetics , gene

Endothelial to mesenchymal transition (EndMT) is a complex biological process that gives rise to cells with multipotent potential. EndMT is essential for the formation of the cardiovascular system during embryonic development. Emerging results link EndMT to the postnatal onset and progression of fibrotic diseases and cancer. Moreover, recent reports have emphasized the potential for EndMT in tissue engineering and regenerative applications by regulating the differentiation status of cells. Transforming growth factor β (TGF-β) engages in many important physiological processes and is a potent inducer of EndMT. In this review, we first summarize the mechanisms of the TGF-β signaling pathway as it relates to EndMT. Thereafter, we discuss the pivotal role of TGF-β-induced EndMT in the development of cardiovascular diseases, fibrosis, and cancer, as well as the potential application of TGF-β-induced EndMT in tissue engineering.

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