Open AccessDetection of active site conformation changes of gamma-secretase, a key enzyme associated with Alzheimer disease, with small molecules
Author(s) -
Natalya Gertsik,
Yueming Li,
De-Ming Chau
Publication year - 2016
Publication title -
frontiers in cellular neuroscience
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.877
H-Index - 86
ISSN - 1662-5102
DOI - 10.3389/conf.fncel.2016.36.00137
Subject(s) - gamma secretase , presenilin , alpha secretase , chemistry , small molecule , active site , amyloid beta , enzyme , alzheimer's disease , biochemistry , amyloid precursor protein , neuroscience , medicine , biology , disease , peptide , pathology