Open AccessHepato- and nephro-toxicity of coumatetralyl rodenticide in some wild rat species
Author(s) -
Hanan Waly,
M. Bassam Al-Salahy,
Wafaa Mohammed Hassan El-Arably,
Magdy Wilson,
Khaled Hassanein
Publication year - 2020
Publication title -
journal of multidisciplinary sciences
Language(s) - English
Resource type - Journals
ISSN - 2671-5449
DOI - 10.33888/jms.2020.226
Subject(s) - rodenticide , toxicity , albumin , creatinine , nephrotoxicity , median lethal dose , biology , urea , pharmacology , lethal dose , lactate dehydrogenase , hemoglobin , medicine , endocrinology , toxicology , chemistry , biochemistry , enzyme
Coumatetralyl (COM) is an anticoagulant rodenticide absorbed quickly after oral dosing. It causes rodent’s death due to internal or external bleeding after complete depletion of plasma vitamin K-dependent coagulation factors. The present study aimed was to shed light on metabolic alterations as the potential hepato- and nephrotoxicity caused by ¼ LD50 COM in Rattus rattus, Arvicanthis niloticus, and Geribellus geribellus wild rat species. Elevation in plasma alanine aminotransferase (ALT), aspartate aminotransferase (AST), albumin, total free amino acids, and erythrocyte lysate glucose-6-phosphate dehydrogenase levels were observed in COM fed rats. Furthermore, plasma creatinine and urea and free hemoglobin levels increased following COM exposure in the challenged rats compared with that in the control ones. It was concluded that ¼ LD50 COM induced hepato- and nephron-toxicity in the fighting rodents.