Open AccessMedication Associated Salivary Gland Alterations– Assessment of risk
Author(s) -
Rooban Thavarajah Prof,
Elizabeth Joshua Prof,
Umadevi Rao Prof,
Kannan Ranganathan Prof
Publication year - 2019
Publication title -
journal of the indian dental association
Language(s) - English
Resource type - Journals
ISSN - 2248-9231
DOI - 10.33882/jida.13.24723
Subject(s) - pharmacovigilance , medicine , adverse event reporting system , adverse effect , odds ratio , haloperidol , clozapine , schizophrenia (object oriented programming) , psychiatry , dopamine
Brief BackgroundMedication Associated Salivary Gland Alterations (MASGA) are a common set of adverse events (AE) associated with many common medications. There are a few reports of the risk of MASGA with medication.Materials and MethodsUsing whole database approach, the Food and Drug Administration Adverse Event Reporting System (FAERS) of the United States of America was searched for MASGA. Common alterations and drugs associated were assessed for the Reporting Odds Ratio, as mentioned in pharmacovigilance researches.ResultsIn the time phase considered, there were in all 16996785 AE reported in the FAERs database. Of this 68624 were related to MASGA with Dry Mouth and hypersecretionbeing most common. Anti-psychotic drugs predominated the hypersecretion spectrum with clozapine having a ROR of 58.04 followed by Haloperidol (25.29). Among the drugs that caused SG enlargement, potassium iodide (1335.32) and Oxyphenbutazone (696.58) had the highest ROR. Non-specific description of altered saliva was seen with high ROR in haloperidol and enoxaparin sodium (14.22).Summary and ConclusionsOdds Ratio of drugs causing MASGA are. chronic medication such as those given for non-communicable, life style diseases and psychiatric medications known to cause MASGA.Key WordsSalivary Alterations, Xerostomia, Salivary gland enlargement, Adverse Events, Pharmacovigilance