Open AccessEfficacy of tofacitinib as a «rescue therapy» in patients with severe ulcerative colitis
Author(s) -
Д. В. Подольская,
М. В. Шапина,
Т. А. Баранова,
И. А. Тишаева,
Т. Л. Александров,
О. В. Князев,
Б. А. Нанаева
Publication year - 2021
Publication title -
koloproktologiâ
Language(s) - English
Resource type - Journals
eISSN - 2686-7303
pISSN - 2073-7556
DOI - 10.33878/2073-7556-2021-20-3-43-50
Subject(s) - medicine , tofacitinib , ulcerative colitis , gastroenterology , rescue therapy , maintenance therapy , surgery , chemotherapy , rheumatoid arthritis , disease
AIM : to evaluate the effectiveness of tofacitinib as a second line treatment. PATIENTS AND METHODS : the study included 12 patients, 4 (33.34%) males and 8 (66.66%) females. The median age was 41 ± 5 years. All patients admitted to the hospital with a severe flare-up of ulcerative colitis, which was the inclusion criterion in this study. Clinical manifestations, laboratory parameters, and colonoscopy were done at the time of administration of tofacitinib, on days 3 and 7, and after 12 weeks. RESULTS : a fast clinical response on 3 day of treatment, reduction in stool frequency, decrease blood in stool was noted in 10 (83.3%) patients. After 7 days from the start of TFCS therapy, all patients showed a decrease from severe activity to mild activity, as well as a decrease in inflammatory blood markers and hemoglobin levels. During the follow-up for 12 weeks, 100% of patients showed positive clinical and laboratory changes. In 10 (83.4%) patients, remission or maintenance of negligible minimal activity was noted. CONCLUSION : the results obtained show that the use of TFTB in hormone-resistant patients can be effective as a second line of “rescue therapy”.