Open AccessISCHEMIC COLITIS IN AN ADULT PATIENT WITH ATYPICAL HEMOLYTIC UREMIC SYNDROME (case report)
Author(s) -
О. С. Озерова,
Е. А. Полторыхина,
А В Варданян,
О. А. Майновская,
В. В. Веселов,
С. В. Чернышов
Publication year - 2019
Publication title -
koloproktologiâ
Language(s) - English
Resource type - Journals
eISSN - 2686-7303
pISSN - 2073-7556
DOI - 10.33878/2073-7556-2019-18-2-82-89
Subject(s) - atypical hemolytic uremic syndrome , microangiopathic hemolytic anemia , medicine , hemolytic anemia , complement system , gastroenterology , gastrointestinal tract , ischemic colitis , anemia , alternative complement pathway , colitis , immunology , thrombotic thrombocytopenic purpura , platelet , antibody
Atypical hemolytic uremic syndrome (aHUS) is a rare life-threatening condition caused by uncontrolled complement activation due to mutations in the alternative pathway of complement components. aHUS is characterized by microangiopathic hemolytic anemia, thrombocytopenia, acute renal failure and affecting multiple organ systems. Extra-renal manifestations of aHUS take place in 20% of patients including involvement of the central nervous system, cardiovascular system, lungs, skin and gastrointestinal tract. This case report describes a severe course of atypical hemolytic uremic syndrome in a 21-year-old female, developed ischemic colitis.