Open AccessPemodelan Homologi Protein Receptor Orphan Receptor-1 (ROR-1) Sebagai Target Terapi Chronic Lymphocytic Leukemia (CLL
Author(s) -
R Ruslin,
Suci Rahmawati Putri,
Muhammad Arba
Publication year - 2019
Publication title -
pharmauho/pharmauho : jurnal farmasi, sains dan kesehatan
Language(s) - English
Resource type - Journals
eISSN - 2715-4181
pISSN - 2442-9791
DOI - 10.33772/pharmauho.v5i1.8992
Subject(s) - ramachandran plot , modeller , orphan receptor , rar related orphan receptor gamma , receptor , chronic lymphocytic leukemia , protein tertiary structure , homology modeling , protein kinase b , leukemia , cancer research , phosphorylation , chemistry , biology , biochemistry , protein structure , enzyme , immunology , transcription factor , gene
Receptor Orphan Reseptor-1 (ROR-1) is a trans-membrane protein consists of 937 amino acid residues located on 1p31.3 chomosome. ROR-1 has an important role in leukemogenesis of CLL cells. Co-expressions of ROR-1 and TCL enhance leukemogenesis and caused AKT’s phosphorylation, cell’s proliferations, and resistances to apoptosis. This study had done physicochemical characteristics analysis, secondary structure and tertiary structure prediction of ROR-1 Protein using few types of bioinformation tools. The physicochemical characteristics analysis was done by using Expasy Protparam server and the prediction of secondary structure was using Sopma and Psipred. The prediction of ROR-1’s tertiary structure was done by using Modeller 9.19 software and resulting five ROR-1’s tertiary structures predicted model. The accuration of the results then evaluated using Ramachandran’s plot analysis and it was showed Model 3 is the best models wich percentage is 82%.Keywords: ROR-1, Choronic Lymphocytic Leukemia (CLL), homology modeling, Modeller, Ramachandran plot