Open AccessThe genetic causes of infertility in patients with oligozoospermia and azoospermia in Turkish population
Author(s) -
Yavuz Onur Danacıoğlu,
Mustafa Gürkan Yenice,
Fatih Akkaş,
Mustafa Soytaş,
Serhat Seyhan,
Ali İhsan Taşçı
Publication year - 2021
Publication title -
yeni üroloji dergisi
Language(s) - English
Resource type - Journals
eISSN - 2687-1955
pISSN - 1305-2489
DOI - 10.33719/yud.2021;16-2-834672
Subject(s) - azoospermia , male infertility , klinefelter syndrome , infertility , y chromosome microdeletion , gynecology , population , genetic counseling , azoospermia factor , incidence (geometry) , genetic testing , medicine , genetics , andrology , biology , obstetrics , pregnancy , physics , environmental health , optics
Objective: Advances in the science of genetics and the development of assisted reproductive techniques focus on the genetic causes of infertility. The aim of this research is to reveal genetic abnormalities in terms of sex chromosome aneuploidy and Y chromosome microdeletions.Material and Methods: A total of 350 patients with azoospermia or severe oligozoospermia were selected. After general examination of the patients and laboratory investigations were performed, cartoypes and Y chromosome microdeletions were examined. Results: A total of 225 infertile men with non-obstructive azoospermia (NOA) and 125 infertile men with oligozoospermia were enrolled into the study. The overall cytogenetic anomaly rate was 16%. Chromosomal changes were detected in 32 of 350 (9.1%) cases. The most common genetic anomaly was 47, XXY (Klinefelter syndrome) and the incidence was 11.5% in NOA group. This rate was 3.2% in oligozoospermia group. Y chromosome microdeletions were detected in 24 (6.8%) patients and similarly, it was observed more frequently in the NOA group than in the oligozoospermia group.Conclusion: The incidence of genetic causes have been increasing with the severity of infertility. As a result, genetic screening and appropriate genetic counseling are needed before the use of assisted reproductive techniques.Keywords: azospermia, chromosome, infertility, microdeletion, oligozoospermiaage