Open AccessColon dysbiosis, increasing of intestinal wall permeability and non-alcohol fatty liver disease
Author(s) -
Yu. P. Uspensky,
Н. В. Барышникова,
Е. В. Балукова
Publication year - 2020
Publication title -
medicinskij alfavit
Language(s) - English
Resource type - Journals
eISSN - 2949-2807
pISSN - 2078-5631
DOI - 10.33667/2078-5631-2019-4-38(413)-48-53
Subject(s) - pathogenesis , intestinal permeability , fatty liver , dysbiosis , disease , lipid metabolism , immune system , inflammation , biology , liver disease , immunology , gut flora , medicine , biochemistry
In the light of modern ideas about the pathogenesis of non-alcoholic fatty liver disease (NAFLD), along with the decoding of the genetic polymorphism of genes that regulate lipid and carbohydrate metabolism, immune factors, metabolic disorders and inflammation, a key role in the pathogenesis of the disease belongs to the intestinal microbiota, which takes part in development of all stages of NAFLD. The article presents the pathogenetic relationships of intestinal microbiota and metabolic disorders.