
Immunopathogenetic role of plasmocytoid dendritic cells in Epstein-Barr virus infection
Author(s) -
О. Н. Учаева,
I. P Tryakina,
Г. В. Сапронов,
О. И. Демина
Publication year - 2020
Publication title -
medicinskij alfavit
Language(s) - English
Resource type - Journals
eISSN - 2949-2807
pISSN - 2078-5631
DOI - 10.33667/2078-5631-2019-3-32(407)-24-28
Subject(s) - immune system , immunology , virus , epstein–barr virus , disease , immunity , biology , medicine , virology , pathology
Plasmocytoid dendritic cells (pDCs) play a key role in immunity against most viruses, given their unparalleled ability to produce large amounts of IFN I type. Studies aimed at studying pDCs in Epstein-Barr virus infection (EBV) are still few. The outcome of EBV largely depends on the ability of the patient’s immune system to form an adequate immune defense, that provides not only a rapid recovery, but also prevents the prolonged course of the disease, leading to the development of immune deficiency and other complications. The development of effective immunorehabilitation of EBV, able to prevent the chronization of this disease, remains one of the most important areas of scientific and practical activities.