Open AccessThree-phase scintigraphy in evaluation of preoperative chemotherapy of soft tissue sarcomas of extremities
Author(s) -
Ya. A. Shchipakhina,
A. S. Krylov,
Н. В. Кочергина,
L. E. Rotobelskaya,
A. B. Bludov,
A. S. Nered,
A. V. Fyodorova
Publication year - 2019
Publication title -
medicinskij alfavit
Language(s) - English
Resource type - Journals
eISSN - 2949-2807
pISSN - 2078-5631
DOI - 10.33667/2078-5631-2019-3-28(403)-33-38
Subject(s) - chemotherapy , medicine , scintigraphy , soft tissue , soft tissue sarcoma , radiology , sarcoma , predictive value , nuclear medicine , surgery , pathology
Purpose. To determine the diagnostic value of threephase scintigraphy in the evaluation of the preoperative chemotherapy of soft tissue sarcomas of the extremities on different diagnostic stages. Material and methods. We analyzed the data of 76 patients with extremity soft tissue sarcomas. The study included data from 28 patients who underwent three-phase scintigraphy with Technetril 99m Tc. Scintigraphic data before and after neoadjuvation chemotherapy were analyzed in 16 patients, before and during chemotherapy — in 6 patients, only during chemotherapy — in 1 and only after all courses of chemotherapy — in 5 patients. Results. The sensitivity of the method (prediction of grade III–IV pathologic response) was 100 %, specificity (prediction of grade I–II pathologic response) was 87%. The predictive value of positive and negative results was 63 and 100%, respectively. Conclusion. A three-phase scintigraphy with Technetril 99m Tc is a highly informative method for evaluating the effectiveness of preoperative chemotherapy in patients with sarcomas of soft tissues of the extremities.