Open AccessSecondary Sjögren's in patients with systemic scleroderma
Author(s) -
Е. И. Селифанова,
M. S. Esayan
Publication year - 2019
Publication title -
medicinskij alfavit
Language(s) - English
Resource type - Journals
eISSN - 2949-2807
pISSN - 2078-5631
DOI - 10.33667/2078-5631-2019-3-23(398)-37-39
Subject(s) - medicine , scleroderma (fungus) , fibrosis , pathology , systemic scleroderma , systemic disease , salivary gland , biopsy , progressive systemic sclerosis , gastroenterology , disease , inoculation
The aim of the study was to investigate the morphological differences of the minor salivary glands in patients with secondary Sjögren's syndrome associated with systemic scleroderma (Scl-SS). Total of 40 patients were grouped according to the American–European Consensus Group criteria. Information about the duration of the disease was taken from the patients records. Sections of the minor salivary gland biopsy were reevaluated, and the lymphocyte focus score (FS), plasma cell focus, and fibrosis rates were all evaluated. The groups were formed according to the duration of the disease: less than and over 5 years. Results. Scl-SS leads to changes in both in the large salivary glands and in the MSG, manifested in the form of mucoid swelling, fibrinoid changes, hyalinosis and sclerosis. In patients with Scl-SS the progression of the process leads to the destruction of the duct wall and to the focal and diffuse lymphoid infiltration.