Open AccessGenetic predisposition and resistance to certain infectious diseases. I. AIDS
Author(s) -
С. Н. Щербо,
Dmitry S. Shcherbo,
A. L. Tishchenko,
М. И. Савина,
Т. И. Туркина
Publication year - 2019
Publication title -
medicinskij alfavit
Language(s) - English
Resource type - Journals
eISSN - 2949-2807
pISSN - 2078-5631
DOI - 10.33667/2078-5631-2019-3-22(397)-6-10
Subject(s) - genetic predisposition , biology , immunology , tuberculosis , virology , genetics , disease , gene , medicine , pathology
The review addresses issues related to genetic predisposition and resistance to infectious diseases. Genetic factors largely determine the susceptibility of the body to various diseases, including infectious ones. A genetic predisposition to tuberculosis, salmonellosis, viral hepatitis, tick-borne encephalitis, Lyme disease, HIV and others is shown. Knowledge of molecular genetic biomarkers is necessary for identifying risk groups, conducting predictive measures, in particular vaccination. The main influence is given to the genes of the main histocompatibility complex; the role of mitochondrial DNA in susceptibility to HIV infection is shown.