Open AccessComparison of modern quantitative methods for determining level of D-dimer based on immunoturbidimetry
Author(s) -
А. Н. Мамаев,
M. V. Pykhteeva,
S. S. Terekhov,
A. V. Kudinov,
D. A. Trukhina,
Elena V. Grigoryeva,
N. N. Yasafova
Publication year - 2019
Publication title -
medicinskij alfavit
Language(s) - English
Resource type - Journals
eISSN - 2949-2807
pISSN - 2078-5631
DOI - 10.33667/2078-5631-2019-3-22(397)-56-57
Subject(s) - d dimer , monoclonal antibody , medicine , comparability , gastroenterology , antibody , immunology , mathematics , combinatorics
The object of this paper is the comparative analysis of the results of determination of the D-dimer level with the new home-produced reagent on the basis of original monoclonal antibodies with the results of the widespread diagnostic analogues. The research study included blood samples of 80 patients. 22 of these patients (27.5 %) were diagnosed venous thrombosises of the lower limbs, 28 patients (35.0 %) did not have any thrombotic complications (control group). Besides, the research included 30 pregnant women (37.5 %) with different duration of gestation. Despite some distinctions when determining the D-dimer level, contemporary quantitative methods of the D-dimer level study demonstrate comparability of the research results which is documented by the high rates of correlation. The new diagnostic kit Tech-D-dimer-auto, based on the use of original monoclonal antibodies, demonstrates good comparability with analogues and is suitable for detection of thrombosis.