Open AccessSpondyloarthritis phenotypes: rationale of evaluation in context of personified medicine
Author(s) -
А. Р. Бабаева,
Е. В. Калинина,
M. S. Zvonorenko,
I. V. Kostriukova
Publication year - 2020
Publication title -
medicinskij alfavit
Language(s) - English
Resource type - Journals
eISSN - 2949-2807
pISSN - 2078-5631
DOI - 10.33667/2078-5631-2019-2-37(412)-16-21
Subject(s) - medicine , hla b27 , psoriatic arthritis , context (archaeology) , ankylosing spondylitis , spondylarthritis , clinical phenotype , spondylitis , radiological weapon , human leukocyte antigen , phenotype , immunology , physical therapy , arthritis , antigen , surgery , genetics , biology , paleontology , gene
The article contents the analysis of different clinical phenotypes in the most common spondyloarthritis (SpA): ankylosing spondylitis (AS), axial spondylarthritis (axSpA) and psoriatic arthritis (PsA). SpA polymorphism has been discussed on the basis of multiple clinical presentations, structural lesions, radiological, immunological and genetic characteristics. Role of pro-inflammatory agents especially IL-17 in structural progression has been pointed out. Recent data regarding the link between HLA-B27 antigen, gender and age specificity and different clinical manifestation of SpA are presented. Current algorithms for SpA management based on evidence of efficacy sDMARD and/or biologics in separate phenotypes of SpA as well as resistance to DMARD are highlighted. Authors have concluded that meticulous analysis of SpA manifestation and patient’s individual profile is critical in rational SpA management according to personified medicine strategy.