Open AccessActivity of respiratory chain complexes of peripheral blood mononuclear cells as marker of mitochondrial dysfunction in acute cardiovascular pathology
Author(s) -
Л. Г. Мишура,
Л. Б. Гайковая,
Г. Г. Родионов,
В. А. Дадали
Publication year - 2019
Publication title -
medicinskij alfavit
Language(s) - English
Resource type - Journals
eISSN - 2949-2807
pISSN - 2078-5631
DOI - 10.33667/2078-5631-2019-2-31(406)-16-19
Subject(s) - respiratory system , myocardial infarction , respiratory chain , peripheral blood mononuclear cell , mitochondrial respiratory chain , medicine , lymphocyte , pathology , troponin , mitochondrion , cardiology , immunology , biology , biochemistry , in vitro
Mitochondrial respiratory chain enzyme activities were determined by spectrophotometric enzyme assay in lymphocytes of 100 patients with acute myocardial infarction. A significant decrease in the activity of complexes II–III and IV and an increase in the activity of complex I of the respiratory chain were found. According to the correlation analysis, the feedback of troponin T and I concentrations in the serum and the activity of complex IV of the respiratory chain was detected. A decrease in the activity of the IV complex of the mitochondrial lymphocyte respiratory chain below 2.87 IU/g of protein indicates an increased level of clinical risk in patients with acute myocardial infarction.