Open AccessFeatures of pathogenesis, progression and structure of pancreatic fibrosis in chronic pancreatitis
Author(s) -
Н. Б. Губергріц,
E. A. Krylova,
Y. А. Gaidar,
A. A. Burka
Publication year - 2019
Publication title -
medicinskij alfavit
Language(s) - English
Resource type - Journals
eISSN - 2949-2807
pISSN - 2078-5631
DOI - 10.33667/2078-5631-2019-2-20(395)-11-15
Subject(s) - pancreatitis , pathology , pancreas , fibrosis , atrophy , hyperplasia , parenchyma , pathogenesis , medicine , endocrine system , epithelium , myofibroblast , hormone
The article is devoted to the results of our own study of structural and fibrotic changes in the pancreatic parenchyma in patients with chronic pancreatitis. It was shown that the formation of fibrous tissue in chronic pancreatitis begins from the ducts and gradually covers the interlobar space and penetrates into the lobes of the pancreas. As fibrosis progresses, the volume fraction of exocrine tissue decreases due to the activation of apoptosis mechanisms and due to fatty degeneration. With a high degree of fibrosis, focal vacuolar dystrophy was detected in the acinar tissue of the pancreatic lobules of all patients, focal apoptosis and lobular apoptosis was observed in 45.4 %. With complete atrophy of the acinar tissue of the pancreatic lobes, hyperplasia of the epithelium of the interlobar and intralobar ducts was observed. The adaptive neoplasm of the endocrine islets (non-idiogenesis) from the epithelium of the intralobular ducts of the pancreas was revealed.