Open AccessDosing of antibiotics in patients with sepsis, including those undergoing renal replacement therapy
Author(s) -
А. О. Шалгинских,
С В Яковлев,
Д. Н. Проценко,
И. Н. Сычев,
М. П. Суворова,
А. О. Быков
Publication year - 2019
Publication title -
medicinskij alfavit
Language(s) - English
Resource type - Journals
eISSN - 2949-2807
pISSN - 2078-5631
DOI - 10.33667/2078-5631-2019-1-16(391)-47-57
Subject(s) - dosing , medicine , antibiotics , renal replacement therapy , sepsis , intensive care medicine , pharmacodynamics , medical prescription , antibiotic therapy , pharmacokinetics , critically ill , pharmacology , microbiology and biotechnology , biology
In critically ill patients the adequacy of starting empirical antimicrobial therapy is a determining factor of the survival of patients with sepsis This article describes the main aspects of the empirical prescription of antibiotics in patients with sepsis who are on renal replacement therapy. Changes in the pharmacokinetic and pharmacodynamic mechanisms that lead to the selection of specific dosing regimens for antibiotics are described. Information on dosing changes for current groups of antibacterial drugs is presented. The purpose of this article is to rationalize antibiotic therapy in a selected group of patients.