Open AccessExperimental pharmacokinetics of the GZK-111 drug preparation exhibiting neuroprotective activity
Author(s) -
Анна Леонидовна Подолько,
П. О. Бочков,
Р. В. Шевченко,
А. А. Литвин,
Г. Б. Колыванов,
В. П. Жердев
Publication year - 2021
Publication title -
biomedicina
Language(s) - English
Resource type - Journals
eISSN - 2713-0428
pISSN - 2074-5982
DOI - 10.33647/2713-0428-17-3e-156-160
Subject(s) - pharmacokinetics , metabolite , neuroprotection , pharmacology , proline , plasma concentration , chemistry , drug , active metabolite , medicine , biochemistry , amino acid
We studied the pharmacokinetics of a drug preparation, ethyl ester of N-phenylacetyl-glycyl-L-proline, exhibiting neuroprotective activity and its metabolite cyclo-L-prolylglycine in rat blood plasma after a single intravenous administration at a dose of 20 mg/kg. The metabolite was found to circulate in the systemic bloodstream of animals twice as long as the ethyl ester of N-phenylacetyl-glycyl-L-proline, with its plasma concentrations being 50–70 times higher than those of the parent compound.