Open AccessCell Therapy of Pathological Gastrointestinal Lesions in Modeled NSAID-Induced Enterocolitis
Author(s) -
R. A. Klesov,
О. И. Степанова,
V. N. Karkischenko,
О. В. Баранова
Publication year - 2021
Publication title -
biomedicina
Language(s) - English
Resource type - Journals
eISSN - 2713-0428
pISSN - 2074-5982
DOI - 10.33647/2074-5982-17-3-48-55
Subject(s) - gastrointestinal tract , mesenchymal stem cell , medicine , stromal cell , bone marrow , regeneration (biology) , enterocolitis , peripheral blood mononuclear cell , pathology , cell , gastroenterology , immunology , biology , in vitro , biochemistry , microbiology and biotechnology , genetics
Wistar rats with NSAID-induced (dexketoprofen) chronic enterocolitis of the gastrointestinal tract were treated with a cultured allogeneic cell suspension consisting of mononuclear cells (40 millions) and multipotent mesenchymal stromal cells (10 millions). The suspension was transplanted intraperitoneally, 2 times with an interval of 30 days. Cultured allogeneic fractions of bone marrow cells accelerate the regeneration of long-term non-healing gastrointestinal lesions by reducing the duration and severity of the inflammatory phase and activating the regenerative phase of the ulcerative process. It was found that the simultaneous administration of the studied cultured stem cells can be used for the treatment of chronic, long-term non-healing, poorly-scarring ulcerative necrotic gastrointestinal pathologies.