Open AccessPharmacological Correction of Long-Term Effects of Acute Severe Poisoning with Sodium Thiopental under Chronic Light Desynchronosis
Author(s) -
Е. Г. Батоцыренова,
В. А. Кашуро,
А. В. Шарабанов
Publication year - 2021
Publication title -
biomedicina
Language(s) - English
Resource type - Journals
eISSN - 2713-0428
pISSN - 2074-5982
DOI - 10.33647/2074-5982-17-3-23-28
Subject(s) - glutathione , glutathione peroxidase , endocrinology , darkness , chemistry , medicine , glucose 6 phosphate dehydrogenase , sodium , dehydrogenase , biochemistry , biology , enzyme , botany , organic chemistry
We experimentally studied the possibility of using a peptide extract from the pituitary gland of a reindeer (Rangifer tarandus) to correct the functional state of the body under the combined effect of acute severe poisoning with sodium thiopental in rats, at a dose of LD 50 under long-term light desynchronosis. The research was conducted using the statistical method of two-factor analysis of variance. It was found that, under constant light, a peptide extract from the pituitary gland of a reindeer affects such parameters as diene conjugates concentration, the activity of glutathione-S-transferase and glucose-6-phosphate dehydrogenase. Under prolonged darkness, the extract under study affected the activity of glutathione-S-transferase, glutathione peroxidase and glucose-6-phosphate dehydrogenase.