Open AccessMechanisms of the Cytotoxic Action of Organotin Compounds
Author(s) -
Е. Р. Милаева,
М. А. Додохова,
D. B. Shpakovsky,
Т. А. Антоненко,
А. В. Сафроненко,
И. М. Котиева,
Е. Ф. Комарова,
Е. В. Ганцгорн,
Margarita Stefanovna Alkhuseyn-Kulyaginova
Publication year - 2021
Publication title -
biomedicina
Language(s) - English
Resource type - Journals
eISSN - 2713-0428
pISSN - 2074-5982
DOI - 10.33647/2074-5982-17-2-88-99
Subject(s) - cytotoxic t cell , cytotoxicity , apoptosis , chemistry , in vivo , in vitro , ligand (biochemistry) , caspase , oxidative stress , microbiology and biotechnology , receptor , biochemistry , biology , programmed cell death , genetics
This review analyzed the literature data on the in vitro preclinical study of the cytotoxic properties of organotin compounds, as well as the main mechanisms of their action. The latter consist in interacting with SH groups of proteins, initiating oxidative stress, binding to DNA, interacting with receptors, as well as activate apoptosis by increasing the expression of caspases, proapoptotic proteins, and decreasing antiapoptotic proteins. Organotin compounds, depending on the donor ligand, exhibit specifi c cytotoxicity towards certain tumor cell lines. The high cytotoxic potential indicates the possibility of further development in vivo and research of organotin compounds as candidates for the creation of drugs for anticancer and antimetastatic therapy.