Open AccessThe experimental study of the antihypoxic properties of harmine hydrochloride
Author(s) -
С. М. Адекенов,
V. N. Karkischenko,
М. С. Нестеров,
Д. А. Абаимов,
А. К. Сариев
Publication year - 2021
Publication title -
biomedicina
Language(s) - English
Resource type - Journals
eISSN - 2713-0428
pISSN - 2074-5982
DOI - 10.33647/2074-5982-17-2-71-78
Subject(s) - harmine , hydrochloride , hypoxia (environmental) , pharmacology , hypercapnia , chemistry , anesthesia , medicine , biochemistry , oxygen , organic chemistry , acidosis
A derivative of the beta-carboline alkaloid harmine — the drug harmine hydrochloride was studied for the presence of antihypoxic properties in models of hypobaric hypoxia and normobaric hypoxia with hypercapnia. It was found that harmine hydrochloride does not have a signifi cant compensatory effect in the normobaric hypoxia test with hypercapnia. At the same time, harmine hydrochloride in small doses (2.5 and 5 mg/kg) has antihypoxic activity in the hypobaric hypoxia test, which is expressed in a statistically signifi cant increase in the life expectancy of animals treated with the drug, compared with the control, in conditions of hypoxia. According to the antihypoxic effect, harmine hydrochloride at doses of 2.5 and 5 mg/kg was found to be comparable with the reference drug (mexidol, 100 mg/kg).