Open AccessDynamics of Biochemical and Cytological Parameters of Rat Blood in Simulated Chronic Alimentary Methionine-Induced Homocysteinemia
Author(s) -
K. A. Pazinenko,
Н. Н. Чучкова,
М. В. Сметанина,
O. A. Pazinenko,
K. E. Panteleev,
Г В Иванов,
Н В Кормилина
Publication year - 2021
Publication title -
biomedicina
Language(s) - English
Resource type - Journals
eISSN - 2713-0428
pISSN - 2074-5982
DOI - 10.33647/2074-5982-17-2-46-57
Subject(s) - methionine , bilirubin , alkaline phosphatase , medicine , excretory system , endocrinology , hyperhomocysteinemia , liver function , cholestasis , chemistry , biochemistry , homocysteine , biology , amino acid , enzyme
Under the conditions of a chronic methionine diet (daily addition of amino acids to food (0.15 g/100 g) and water (1% solution)) during 2–12 weeks, the dynamics of liver tests, infl ammatory changes in the blood and blood lipids was monitored. It was found that a methionine diet (MD) leads, starting from 4 weeks of MD, to medium hyperhomocysteinemia, an increase in liver enzymes (AsAT – 1.73, AlAT – 1.5 times, p<0.05) and bilirubin (by 62.25%), which indicates the formed hepatopathy. Further (12 weeks of MD), the condition is aggravated by an abnormality of excretory liver function and the development of cholestasis (an increase in alkaline phosphatase by 1.65, bilirubin – by 3.31 times, p<0.05).