Open AccessInformation Algorithm for Non-Invasive Evaluation of Osteoresorbable Side Effects of Glucocorticosteroids in Patients with Ulcerative Colitis
Author(s) -
А. В. Сафроненко,
В. А. Косенко,
А А Демидова,
И. А. Демидов,
Н. В. Сухорукова,
Е. В. Ганцгорн
Publication year - 2020
Publication title -
biomedicina
Language(s) - English
Resource type - Journals
eISSN - 2713-0428
pISSN - 2074-5982
DOI - 10.33647/2074-5982-16-3-92-96
Subject(s) - ulcerative colitis , medicine , osteoporosis , bone resorption , gastroenterology , cathepsin , resorption , enzyme , chemistry , biochemistry , disease
A study involving 45 patients with ulcerative colitis found that the activity of the Cathepsin K bone resorption marker measured by an enzyme-linked immunosorbent assay in gingival uid could be used as a non-invasive control over the development of steroid osteoporosis caused by systemic use of glucocorticoids. When the concentration of Cathepsin K in the gingival uid exceeded 3.7 pmol/L, the risk of developing osteoporosis in patients with ulcerative colitis taking glucocorticosteroids on a regular basis increased by 7.9 times with a diagnostic accuracy of 82.6% (p=0.002). As a result of the study, an effective method for non-invasive assessment of osteoresorbable side effects of glucocorticosteroids in autoimmune diseases was proposed.