Open AccessEffects of L-Ornithine L-Aspartate on the Physical Performance with Experimental Non-Alcoholic Fatty Liver Disease
Author(s) -
V. A. Prikhodko,
М. А. Поверяева,
Ю. И. Сысоев,
Е. Б. Шустов,
А. В. Бунят
Publication year - 2020
Publication title -
biomedicina
Language(s) - English
Resource type - Journals
eISSN - 2713-0428
pISSN - 2074-5982
DOI - 10.33647/2074-5982-16-3-77-80
Subject(s) - fatty liver , carbon tetrachloride , ornithine , alcoholic liver disease , medicine , liver disease , endocrinology , chemistry , disease , biochemistry , cirrhosis , amino acid , organic chemistry , arginine
In the present study, we evaluated the effects of L-ornithine L-aspartate on the physical performance of C57BL/6 mice with experimental non-alcoholic fatty liver disease (NAFLD) induced by a high-caloric “western” diet combined with intraperitoneal carbon tetrachloride injections. Using the forced swim test and triple weight-loaded exhaustive swim test, this model of NAFLD was shown to cause a signicant impairment of physical performance and a decrease in physical recovery. L-ornithine L-aspartate was found to signicantly improve physical performance and benet post-exercise recovery in mice with NAFLD.