Open AccessExperimental Screening Study of the Antiarhythmic Activity of Empagliflosin
Author(s) -
М. В. Краснова,
С. В. Оковитый,
Alexander N. Kulikov,
Д. Ю. Ивкин,
Ekaterina Kashina
Publication year - 2020
Publication title -
biomedicina
Language(s) - English
Resource type - Journals
eISSN - 2713-0428
pISSN - 2074-5982
DOI - 10.33647/2074-5982-16-3-73-76
Subject(s) - sodium , pharmacology , calcium , chemistry , transporter , biological activity , drug , medicine , biochemistry , in vitro , organic chemistry , gene
The antiarrhythmic activity of the type 2 sodium glucose co-transporter inhibitor Empagliozin was studied in a model induced by calcium chloride in C57BL mice. It was found that preliminary administration of Empagliozin at a dose of 1 mg/kg prevented CaCl2-induced ventricular arrhythmia and death during four periods of the biological half-life of the drug.