Open AccessBehavioural Changes in Heterozygous Rats by Gene Knockout of the Dopamine Transporter (DAT)
Author(s) -
Azamat R. Gainetdinov,
Zoia Fesenko,
З. Р. Хисматуллина
Publication year - 2020
Publication title -
biomedicina
Language(s) - English
Resource type - Journals
eISSN - 2713-0428
pISSN - 2074-5982
DOI - 10.33647/2074-5982-16-1-82-88
Subject(s) - dopamine transporter , dopamine , knockout mouse , elevated plus maze , medicine , endocrinology , transporter , gene knockout , biology , psychology , anxiety , gene , genetics , psychiatry , dopaminergic , receptor
This paper presents the results of a comparative analysis of behavioural indicators in rats with modelled genetic dopamine transporter (DAT) deciency. Two groups of laboratory animals — heterozygous DAT knockout rats (DAT-HET) and Wistar rats — underwent the “Open eld”, “Elevated plus maze” and “Extrapolation deliverance” tests. It is established that DAT-HET rats are characterized by an increased locomotor and research activity along with reduced anxiety and cognitive impairment compared to Wistar rats used as control.