Open AccessSEARCH FOR NEW OLIGOPEPTIDE MOLECULES FOR PHARMACOLOGICAL CORRECTION OF NSAIDS-INDUCED GASTRIC ULCER
Author(s) -
A. Yu. Zharikov,
S.E. Lorents,
И. П. Бобров,
O.N. Mazko,
О Г Макарова
Publication year - 2019
Publication title -
biomedicina
Language(s) - English
Resource type - Journals
eISSN - 2713-0428
pISSN - 2074-5982
DOI - 10.33647/2074-5982-15-3-90-97
Subject(s) - omeprazole , tetrapeptide , medicine , ulcer index , drug , oligopeptide , pharmacology , gastroenterology , gastric mucosa , peptide , stomach , chemistry , biochemistry
This article presents the results of a study aimed at determining the gastroprotective activity of a number of short-chain peptides against the background of experimental gastropathy in rats. Indomethacin ulcer was used as a model of ulceration. Omeprazole, a drug of basic therapy, was used as a comparison drug. According to the results of the study, two peptides — tetrapeptide LA-4 and hexapeptide LF-6 — demonstrated the gastroprotective activity. The effect was manifested in a signifi cant decrease in the average number of erosions on the surface of the gastric mucosa, their depth, the number of stripe-shaped erosions and Paul’s Index. At the same time, the LF-6 peptide had an effect comparable to that of omeprazole, which makes it promising and interesting for further study.