Open AccessRole of Cytokines of the IL-1 Family in Implantation and Development of Induced Pregnancy
Author(s) -
А. В. Лапштаева,
Juliya Jurevna Danilova
Publication year - 2021
Publication title -
bûlletenʹ nauki i praktiki
Language(s) - English
Resource type - Journals
ISSN - 2414-2948
DOI - 10.33619/2414-2948/62/17
Subject(s) - endometrium , chemokine , embryo , matrix metalloproteinase , pregnancy , immune system , secretion , menstrual cycle , interleukin , medicine , biology , immunology , cytokine , microbiology and biotechnology , endocrinology , genetics , hormone
Cytokines of the interlekin-1 (IL-1) family play an important role in the regulation of the immune response, including by inducing the synthesis of other cytokines, chemokines, and matrix metalloproteinases. All components of IL-1 are found in the endometrium throughout the entire menstrual cycle. endometrial factors Stimulate the secretion of IL-1 by the embryo, which contributes to the formation of the relationship between the mother's endometrium and the embryo before implantation. The article presents the results of an analysis of modern literature sources devoted to the role of IL-1α, IL-1β, IL-1Rа in the process of implantation and the development of spontaneous and induced pregnancy.