Open AccessSYNTHESIS OF 4-HETARYL-2-(DICHLOROMETHYL)PYRAZOLO[1,5-a][1,3,5]-TRIAZINES
Author(s) -
Yevheniia Velihina,
Maryna Kachaeva,
С. Г. Пильо,
Виктория С. Москвина,
O. V. Shablykina,
В. С. Броварец
Publication year - 2020
Publication title -
ukraïnsʹkij hìmìčnij žurnal
Language(s) - English
Resource type - Journals
eISSN - 2708-129X
pISSN - 2708-1281
DOI - 10.33609/2708-129x.86.5.2020.53-62
Subject(s) - moiety , substituent , furan , reagent , chemistry , pyridine , medicinal chemistry , combinatorial chemistry , stereochemistry , organic chemistry
New pyrazolo[1,5-a][1,3,5]triazines with a heteroaromatic substituent in position 4 and dichloromethyl moiety in position 2 were obtained via a heterocyclization reaction of readily available reagents - N-(2,2-dichloro-1-cyanoethenyl)carboxamides and 3(5)-aminopyrazoles. The high efficiency of the proposed method for the synthesis of 2-(dichloromethyl)-pyrazolo[1,5-a][1,3,5]triazines with furan-2-yl, thien-2-yl, and pyridine-3-yl substituents was demonstrated.