Open AccessIncrease of Kynurenic Acid after Encephalomyocarditis Virus Infection and Its Significances
Author(s) -
Halina Baran,
Markus Draxler,
Carina Kronsteiner,
Berthold Kepplinger
Publication year - 2021
Publication title -
neurosignals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.755
H-Index - 67
eISSN - 1424-8638
pISSN - 1424-862X
DOI - 10.33594/000000434
Subject(s) - kynurenic acid , kynurenine , neopterin , beta 2 microglobulin , immune system , metabolite , virus , stimulation , nasal administration , inflammation , biology , medicine , virology , chemistry , immunology , tryptophan , amino acid , biochemistry
The moust symptoms of piglets infected with Encephalomyocarditis virus (EMCV) are related to breeding difficulty, circulation insufficiency, depression and occurrence of high lethality. An increase of tryptophan metabolism in the periphery and in the central nervous system (CNS) in human and non-human subjects with inflammatory diseases has been suggested. We investigated an alterations of tryptophan metabolite i.e. kynurenic acid (KYNA) level in the serum of piglets after EMC virus infection. In addition, we investigated the markers of immune stimulation i.e. neopterin and β2-microglobulin.